Non-voltage-gated Ca2+ entry pathways in the heart: the untold STOrai?

Non-voltage-gated Ca²⁺ entry pathways in the heart: the untold STOrai?

Non - voltage gated Ca 2 + entry pathways in the heart : The untold STOrai ?

Voltage-gated Ca2+ entry and ryanodine receptor Ca2+-induced Ca2+ release in preglomerular arterioles.

We have previously shown that in afferent arterioles, angiotensin II (ANG II) involves activation of the inositol trisphosphate receptor (IP(3)R), activation of adenine diphosphoribose (ADPR) cyclase, and amplification of the initial IP(3)R-stimulated release of cytosolic Ca(2+) ([Ca(2+)](i)) from the sarcoplasmic reticulum (SR) (Fellner SK, Arendshorst WJ. Am J Physiol Renal Physiol 288: F785-...

Functional role of voltage gated Ca2+ channels in heart automaticity

Pacemaker activity of automatic cardiac myocytes controls the heartbeat in everyday life. Cardiac automaticity is under the control of several neurotransmitters and hormones and is constantly regulated by the autonomic nervous system to match the physiological needs of the organism. Several classes of ion channels and proteins involved in intracellular Ca(2+) dynamics contribute to pacemaker ac...

Non-voltage-gated calcium channels in snail heart ventricle cells.

1. Two recently identified channel types in Lymnaea stagnalis heart muscle cells were shown to conduct Na+ in the absence of extracellular Ca2+. They did not appear to be 'voltage-gated' as they were not activated by voltage. Also, they remained active over a wide range of membrane potentials. However, they were weakly 'voltage-sensitive' as their activity usually tended to increase with depola...